Powerful allrounder Grace Harris hammered a 37-ball 53 as Brisbane chased their target of 133 with 18 balls to spare.
Sent in by the Heat, the new Scorchers opening pair of Beth Mooney and Sophie Devine got off to a flier, putting on 42 runs in the first six overs.
Their new partnership was broken on 55 when Devine (26) swung hard at a full toss from Amelia Kerr, before a brilliant direct hit from Georgia Prestwidge caught Beth Mooney (37) short of her crease.
Amy Jones and Nicole Bolton struck 25 each, but no other batter reached double figures as the Scorchers were kept to 7-132.
The Heat unveiled their own new opening pair of Maddy Green and Georgia Redmayne, and while the former was caught and bowled by Piepa Cleary for six, the latter thrived against her old side.
She put on 30 for the second wicket with captain Jess Jonassen (21) before Harris strode to the crease with the required run rate sitting around seven.
Hyped up by coach Ashley Noffke before the start of the season, Harris duly delivered with brilliant display of finesse and sheer strength, clearing the rope three times to bring up a half-century.
She departed with just 10 runs required, but anchor Redmayne (37no) ensured no further hiccups.