The Heat are coming into the match with five wins in succession and currently hold down second spot, with two regular season games remaining.
Brisbane take on the Melbourne Renegades on Sunday, also at Drummoyne Oval.
The Heat overcame the Sydney Sixers and the Perth Scorchers during the week to move into the top two, with siblings Grace Harris and Laura Kimmince claiming the respective player of the match awards.
The Stars are five points clear of the Heat, while the third-placed Sydney Thunder trail Brisbane by two points.
The semi-finals next week will be on Wednesday and Thursday nights at North Sydney Oval with the Final on Saturday evening at the same venue.
Brisbane Heat v Melbourne Stars
Tomorrow 8.30am Qld time
Live Coverage: Foxtel, Kayo, cricket.com.au, ABC Radio
Jess Jonassen (c)
Nadine de Klerk